PI: George Macones, MD, MSCE
Title: Pregnancy after LEEP
Purpose: To assess whether LEEP increases the risk of spontaneous pre-term birth and other adverse pregnancy outcomes, compared to women who have not had a LEEP procedure.
Patient Selection: Women, 18 to 40 years old in years 1996-2001, who have undergone LEEP, cervical punch biopsy after colposcopy (without LEEP), or Pap smear and are identified from surgical pathology databases.
P.I.: George Macones MD, MSCE
Title: Twin Birth Study
Purpose: To determine the best delivery management for twin pregnancies between 32-38 weeks pregnant where Twin A is cephalic, in order to reduce maternal and fetal/neonatal mortality and morbidity.
Patient Selection: Women with twin pregnancies where Twin A is cephalic and they are between 32 and 38 weeks pregnant, each fetus should weigh between 1,500g - 4,000g and who will be willing to willing to have intermittent contact until 2 years following delivery.
P.I. George Macones, MD, MSCE
Title: The Efficacy of Early Amniotomy for Induction of Labor
Purpose: To investigate the efficacy of artificial rupture of membranes, when the cervix is = 4 cm, on reducing both the duration of labor and the frequency of dystocia in nulliparous women undergoing induction of labor.
Patient Selection: Patients admitted to Labor & Delivery for scheduled induction of labor who are = 37 weeks gestation.
PI: George Macones, MD, MSCE
Title: The Timing of Prophylactic Antibiotics in Cesarean Section and the Risk of Postoperative febrile morbidity; a randomized controlled trial
Purpose: To determine whether the timing of prophylactic antibiotic administration for C/S (immediate preoperative vs. intraoperative administration) impacts the rate of postoperative febrile morbidity.
Patient Selection: All patients undergoing non-emergent cesarean section at greater than 36 weeks gestation.
PI: Anthony Odibo, M.D.
Title: Optimal timing of the delivery of the preterm growth-restricted pregnancy: A prospective cohort study.
Purpose: To compare the ability of two antepartum tests, Doppler flow studies of feto-placental vessels and biophysical profile, to optimally determine the timing of delivery of pregnancies with preterm intrauterine growth-restriction (IUGR).
Patient Selection: Patients with the diagnosis of IUGR will be identified through the Division of Genetics, Maternal-Fetal Medicine and Ultrasound at Washington University School of Medicine.
P.I. Alison Cahill, MD
Title: Pregnancy Outcomes after Prolonged Admission for Fetal Decelerations
Purpose: To examine the maternal, fetal, and labor outcomes in cases of prolonged admission for electronic fetal monitoring (EFM) after one or more fetal heart rate decelerations.
Patient Selection: This is a retrospective chart review of all patients admitted to Labor & Delivery for continuous EFM secondary to repetitive fetal heart rate decelerations from January 1, 2004 through April 1, 2006.
PI: Alison Cahill, MD
Title: The Prediction of Macrosomia and Birth Trauma in Diabetic Pregnancies
Purpose: To assess whether fasting blood glucose levels, HgA1c levels, fructosamine levels, or 3-D ultrasound measurements, can accurately predict fetal macrosomia, birth trauma, or combined neonatal morbidity outcomes.
Patient Selection: Patients with pre-gestational or gestational diabetes with a confirmed pregnancy will be eligible for this study.
PI: Alison G. Cahill, M.D.
Title: Imaging for Diagnosing Pulmonary Embolism in Pregnancy
Purpose: To identify the trends in imaging modality for the diagnosis of pulmonary embolism in the pregnant patient at Barnes-Jewish Hospital.
Patient Selection: Pregnant patients who received radiologic imaging to establish the diagnosis of pulmonary embolism, between January 1, 2001 and September 1, 2006, at Barnes Jewish Hospital.
P.I.: Clayton Skaggs, DC
Title: Musculoskeletal and obstetric management study (MOMS)
Purpose: To determine whether a multi-modal intervention will reduce pain, impairment and disability during and after pregnancy for those patients who have back and pelvic pain in pregnancy.
Patient Selection: Women who are between 24-28 weeks pregnant, aged between 15-45 years and have low back pain or pelvic pain and will be willing to participate in the study until 3 months after delivery.