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moley.jpgKelle H. Moley, M.D.

Title:
James P. Crane Professor, Department of Obstetrics and Gynecology
Vice Chair of Basic Science Research
Director, Basic Research Division

Education:
B.A. Wellesley College
M.D. Yale University

Residency:
Obstetrics and Gynecology, Washington University School of Medicine (1988-1992)

Fellowship:
Reproductive Endocrinology/Fertility, Washington University School of Medicine (1992-1994)

Board Certification:
American Board of Obstetrics and Gynecology
General Obstetrics and Gynecology
Board Certified, November 2001
Reproductive Endocrinology and Infertility
Board Certified, April 2003

Societies, Memberships, and Honors:
Society for Gynecological Investigation, Program Chair 2007 and Council Member 2006-2007
American Diabetes Association, Professional Member
American Society of Reproductive Medicine     , Member                                
FASEB, Member
American Society for Clinical Investigation, Scholar
Society for the Study of Reproduction, Member
Society for Reproductive Endocrinology and Infertility, Member                                   

Synopsis: 
Kelle H. Moley, M.D., a professor of obstetrics and gynecology and was named vice chair for basic science research and director of the Division of Basic Science Research in the Department of Obstetrics and Gynecology at Washington University School of Medicine in St. Louis in March of 2006 and the inaugural James P. Crane Professor of Obstetrics and Gynecology in June 2009. As part of her appointment, Moley is responsible for developing a strategic plan and direction for the new division and enhancing the current program in Reproductive Science.

Also a professor in cell biology and physiology, Moley is one of a handful of people in the world studying the effects of maternal type 1 and type 2 diabetes on the implantation and development of mice embryos. Her work has established that short term exposure to high concentrations of glucose or insulin during the first 72 hours following fertilization is enough to alter the embryos and result in the increase in congenital malformations and miscarriages, as seen in women with diabetes and other metabolic disorders.

She also is known for cloning and characterizing two novel glucose transporters, GLUT8 and GLUT9, the later of which she discovered in collaboration with her husband, Jeffrey Moley, M.D., professor of surgery. Her work on these proteins demonstrates altered location and expression of these transporters in response to insulin exposure and diabetes, respectively. Her research has impacted our understanding of reproductive performance and glucose utilization in diabetic animal models and how this may be applicable to the pathophysiology of diabetes in humans.  She is principal investigator on several NIH grants exploring reproductive biology.

Moley is director of the Fellowship Program in Reproductive Endocrinology and the Clinical Mentorship Program for the University's Markey Pathway, a graduate program that provides students with a deeper understanding of the nature of disease. She also is co-principal investigator on the first National Institutes of Health training grant for PhDs interested in Reproductive Sciences awarded to the Department of Obstetrics and Gynecology at Washington University School of Medicine.

Additionally, Moley is a member of the American Society of Clinical Investigation and is on the board of directors of Frontiers in Reproduction, an international educational program for reproductive scientists.

She joined the University faculty in 1992 as an instructor in obstetrics and gynecology and as a postdoctoral fellow in cell biology and physiology following a residency and fellowship at the School of Medicine.  Moley earned a bachelor's degree in biochemistry from Wellesley College in Wellesley, Mass., in 1984 and a medical degree from Yale University School of Medicine in 1988.

E-Mail: Moleyk@wudosis.wustl.edu