David G. Mutch, M.D., Director
Selected Publications
Mutch, DG, Massad, L.S., Powell, C.B., Kao, M.S. and Collins, J.L.: Prolif¬erative and antiproliferative effects of interferon gamma and tumor necrosis factor-a on cell lines derived from cervical and ovarian malignancies. Am J OB GYN 1990;163:1920-1924
Mutch, DG, Powell, C.B., Kao, M.S. and Collins, J.L.: Resistance to lysis by TNFa in malignant gynecologic cell lines is associated with the expression of protein(s) that prevent the activation ofphospholipase A2 by TNFa. Cancer Res. 1992; 52:866-872.
Morris M, Eifel PJ, Lu J, Levenback C, Grigsby PW, Stevens, RE, Rotman M, Gershenson DM, Mutch DG: Pelvic radiation with concurrent chemotherapy versus pelvic para-aortic radiation for high-risk cervical cancer: A Randomized Radiation Therapy Oncology Group Trial. NEJM 1999;340:1137-1143.
Goodfellow PJ, Buttin BM, Herzog TJ, Rader JS, Gibb RK, Swisher E, Look K, Walls KC, Fan M-Y, Mutch DG: Prevalence of defective DNA mismatch repair and MSH6 mutation in an unselected series of endometrial cancers. PNAS 100 (10): 5908-5913, 2003.
Mutch, DG, Powell, M.A., Mallon, M.A. and Goodfellow, P.J. RAS/RAF mutation and defective DNA mismatch repair in endometrial cancers. Am J Obst and Gyn, 2004 Apr, 190(4):935-942.
Guillem JG, Mutch DG et al. ASCO/SSO review of current role of risk-reducing surgery in common hereditary cancer syndrome. Journal of ClinicalOncology. 24(28):4642-4660, October 1, 2006.
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Andrea R. Hagemann, M.D.
Selected Publications
Hagemann AR, Hagemann IS, Cadungog M, Hwang WT, Patel P, Lal P, Hammond R, Gimotty PA, Chu CS, Rubin S, Birrer MJ, Powell DJ Jr, Feldman MD, Coukos G. Tissue-based immune monitoring II: Multiple tumor sites reveal immunologic homogeneity in serous ovarian carcinoma. Cancer Biol Ther. 2011 Aug 15;12(4). In press.
Hagemann AR, Cadungog M, Hagemann IS, Hammond R, Adams SF, Chu CS, Rubin S, Zhang L, Addya K, Birrer MJ, Gimotty PA, Coukos G. Tissue-based immune monitoring I: Tumor core needle biopsies allow in-depth interrogation of the tumor microenvironment. Cancer Biol Ther. 2011 Aug 15;12(4). In press.
Tanyi JL, McCann G, Hagemann AR, Coukos G, Rubin SC, Liao JB, Chu CS. Clinical predictors of bevacizumab-associated gastrointestinal perforation. Gynecol Oncol. 2011 Mar;120(3):464-9.
Hagemann AR, Zighelboim I, Odibo AO, Rader JS, Mutch DG, Powell MA. Cost-benefit of laparoscopic versus medical ovarian suppression in premenopausal breast cancer. Breast J. 2011 Jan-Feb;17(1):103-5. doi: 10.1111/j.1524-4741.2010.01017.x.
Liao JB, Jean S, Wilkinson-Ryan I, Ford AE, Tanyi JL, Hagemann AR, Lin LL, McGrath CM, Rubin SC. Vaginal intraepithelial neoplasia (VAIN) after radiation therapy for gynecologic malignancies: a clinically recalcitrant entity. Gynecol Oncol. 2011 Jan;120(1):108-12.
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L. Stewart Massad, M.D.
Selected Publications
Wright TC, Massad LS, Dunton CJ, Spitzer M, Wilkinson EJ, Solomon D for the 2006 ASCCP-sponsored consensus conference. 2006 consensus guidelines for the management of women with abnormal cervical cancer screening tests. Am J Obstet Gynecol, 2007;197:346-55. Expanded version J Lower Genital Tract Dis 2007;11:201-22.
Massad LS, Jeronimo J, Schiffman M for the National Institutes of Health / American Society for Colposcopy and Cervical Pathology (NIH/ASCCP) Research Group. Interobserver Agreement in the Assessment of Components of Colposcopic Grading. Obstet Gynecol. 2008;111:1279-84.
Massad LS, Seaberg EC, Watts DH, Minkoff H, Levine AM, Henry D, Colie C, Darragh TM, Hessol NA. Long-term incidence of cervical cancer in women with HIV. Cancer 2009;115:524-30.
Massad LS, Evans CE, Weber KM, Goderre JL, Hessol NA, Henry D, Colie C, Strickler HD, Watts DH, Wilson TE. Changes in knowledge of cervical cancer prevention and human papillomavirus among women with HIV, 2006-2008. Obstet Gynecol 2010;116:941-7
Massad LS, Agniel D, Minkoff H, Watts DH, D’Souza G, Levine AM, Darragh TM, Young M, Cajigas A, Weber K. Effect of stress and depression on the frequency of squamous intraepithelial lesions. J Lower Genit Tract Dis 2011;15:42-7.
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Matthew A. Powell, M.D.
Selected Publications
Wright JD, Tian C, Mutch DG, Herzog TJ, Nagao S, Fujiwara K, Powell MA, Carboplatin dosing in obese women with ovarian cancer: a Gynecologic Oncology Group study. Gynecol Oncol. 2008 Jun;109(3):353-8. Epub 2008 Apr 14.
Powell MA, Filiaci VL, Rose PG, Mannel RS, Hanjani P, Degeest K, Miller BE, Susumu N, Ueland FR. Phase II evaluation of paclitaxel and carboplatin in the treatment of carcinosarcoma of the uterus: A Gynecologic Oncology Group Study. J Clin Oncol. 2010 Apr 26.
Zighelboim I, Kizer N, Taylor NP, Case AS, Gao F, Thaker PH, Rader JS, Massad LS, Mutch DG, Powell MA. “Surgical Apgar Score" predicts postoperative complications after cytoreduction for advanced ovarian cancer. Gynecol Oncol. 2010 Mar;116(3):370-3.
Powell MA. Paclitaxel plus Carboplatin as systemic therapy for endometrial cancer. Clinical Ovarian Cancer, Vol 3, No. 1, 21-28. May, 2010. DOI: 10.3816/COC.2010.
Hagemann AR, Zighelboim I, Odibo AO, Rader JS, Mutch DG, Powell MA. Cost-benefit of laparoscopic versus medical ovarian suppression in premenopausal breast cancer. Breast J. 2011 Jan;17(1):103-5.
Zighelboim I, Powell MA. Adjuvant Treatment for Early-stage Endometrial Cancer. Clin Obstet Gynecol. 2011 Jun;54(2):245-55.
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Premal H. Thaker, M.D.
Selected Publications
Sood AK, Bhatty R, Kamat AA, Landen CN, Han L, Thaker PH, Li Y, Gershenson DM, Lutgendorf SK, Cole SW. Stress hormone-mediated invasion of ovarian cancer cells. Clin Cancer Res 12(2): 369-75, 2006.
Thaker PH, Han LY, Kamat AA, Arevalo J, Takahashi R, Lu C, Jennings NB, Armaiz-Pena G, Bankson JA, Ravoori M, Merritt WM, Lin YG, Mangala LS, Kim TJ, Coleman RL, Landen CN, Li Y, Felix E, Newman RA, Lloyd M, Gershenson DM, Kundra V, Lopez-Berestein G, Lutgendorf SK, Cole S, Sood AK. Chronic stress promotes tumor growth and angiogenesis in ovarian carcinoma. Nat Med. 12(8): 939-44, 2006.
Thaker PH and Sood AK. Neuroendocrine Influences on Cancer Biology. Semin Cancer Biol. 18(3): 164-70, 2008.
Nugent E, Hoff JT, Gao F, Massad LS, Case A, Zighelboim I, Mutch DG, Thaker PH. Wound complications after gynecologic surgery. Gynecol Oncol Feb 2011
Ramondetta L, Brown A, Richardson G, Urbauer D, Thaker PH, Koenig H, Gano JB, Sun C. Religious and Spiritual beliefs of gynecologic oncologists may influence medical decision making. Int J Gynecol Cancer 21(3):573-81, 2011.
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Israel Zighelboim, M.D.
Selected Publications
Zighelboim I, Goodfellow PJ, Gao F, Gibb RK, Powell MA, Rader JS, Mutch DG. The impact of microsatellite instability and epigenetic inactivation of MLH1 on the outcome of patients with endometrial carcinomas of the endometrioid type. J Clin Oncol 2007; 25: 2042-8.
Zighelboim I, Schmidt AP, Gao F, Thaker PH, Powell MA, Rader JS, Gibb RK, Mutch DG, Goodfellow PJ. ATR Mutation in Endometrioid Endometrial Cancer is Associated with Poor Clinical Outcomes. J Clin Oncol 2009; 27: 3091-3096.
Zighelboim I, Kizer N, Taylor NP, Case AS, Gao F, Thaker PH, Rader JS, Massad LS, Mutch DG, Powell MA. "Surgical Apgar Score" Predicts Postoperative Complications after Cytoreduction for Advanced Ovarian Cancer. Gynecol Oncol 2010; 116: 370-3.
Zighelboim I, Reinhart AJ, Gao F, Schmidt AP, Mutch DG, Thaker PH, Goodfellow PJ. DICER1 Expression and Outcomes in Endometrioid Endometrial Adenocarcinoma. Cancer 2011; 117: 1446-53.
Zighelboim I, Powell MA. Adjuvant treatment for early stage endometrial cancer. Clin Obstet Gynecol 2011; 54: 245-55.
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Israel Zighelboim, M.D. Pub Med Search